Discovery of novel brain permeable and G protein-biased beta-1 adrenergic receptor partial agonists for the treatment of neurocognitive disorders

The beta-1 adrenergic receptor (ADRB1) is a promising therapeutic target intrinsically involved in the cognitive deficits and pathological features associated with Alzheimer’s disease (AD). Evidence indicates that ADRB1 plays an important role in regulating neuroinflammatory processes, and activatio...

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Publicado en:PLoS One
Autores principales: Yi, Bitna, Jahangir, Alam, Evans, Andrew K., Briggs, Denise, Ravina, Kristine, Ernest, Jacqueline, Farimani, Amir B., Sun, Wenchao, Rajadas, Jayakumar, Green, Michael, Feinberg, Evan N., Pande, Vijay S., Shamloo, Mehrdad
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5529018/
https://ncbi.nlm.nih.gov/pubmed/28746336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180319
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