Modulation of neuroinflammation and pathology in the 5XFAD mouse model of Alzheimer’s Disease using a biased and selective beta-1 adrenergic receptor partial agonist

Degeneration of noradrenergic neurons occurs at an early stage of Alzheimer’s Disease (AD). The noradrenergic system regulates arousal and learning and memory, and has been implicated in regulating neuroinflammation. Loss of noradrenergic tone may underlie AD progression at many levels. We have prev...

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Vydáno v:Neuropharmacology
Hlavní autoři: Ardestani, Pooneh Memar, Evans, Andrew K., Yi, Bitna, Nguyen, Tiffany, Coutellier, Laurence, Shamloo, Mehrdad
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5385159/
https://ncbi.nlm.nih.gov/pubmed/28089846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2017.01.010
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