Axonally derived matrilin-2 induces proinflammatory responses that exacerbate autoimmune neuroinflammation

In patients with multiple sclerosis (MS) and mice with experimental autoimmune encephalomyelitis (EAE), inflammatory axonal injury is a major determinant of disability; however, the drivers of this injury are incompletely understood. Here, we used the EAE model and determined that the extracellular...

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Pubblicato in:J Clin Invest
Autori principali: Jonas, Anna, Thiem, Stefan, Kuhlmann, Tanja, Wagener, Raimund, Aszodi, Attila, Nowell, Cameron, Hagemeier, Karin, Laverick, Louise, Perreau, Victoria, Jokubaitis, Vilija, Emery, Ben, Kilpatrick, Trevor, Butzkueven, Helmut, Gresle, Melissa
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347228/
https://ncbi.nlm.nih.gov/pubmed/25329699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI71385
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