The COX-2-derived PGE(2) autocrine contributes to bradykinin-induced matrix metalloproteinase-9 expression and astrocytic migration via STAT3 signaling

BACKGROUND: The matrix metalloproteinase-9 (MMP-9) is up-regulated by several proinflammatory mediators in the central nervous system (CNS) diseases. Increasing reports show that MMP-9 expression is an inflammatory biomarker of several CNS disorders, including the CNS inflammation and neurodegenerat...

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Foilsithe in:Cell Commun Signal
Main Authors: Lee, Tsong-Hai, Liu, Pei-Shan, Tsai, Ming-Ming, Chen, Jiun-Liang, Wang, Su-Jane, Hsieh, Hsi-Lung
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2020
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7685582/
https://ncbi.nlm.nih.gov/pubmed/33228717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-020-00680-0
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