Rottlerin, a natural polyphenol compound, inhibits upregulation of matrix metalloproteinase-9 and brain astrocytic migration by reducing PKC-δ-dependent ROS signal

BACKGROUND: Upregulation of matrix metalloproteinase-9 (MMP-9) has been indicated as one of the inflammatory biomarkers. In the central nervous system (CNS), the MMP-9 is induced by several proinflammatory mediators and participates in the CNS disorders, including inflammation and neurodegeneration....

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Lee, Tsong-Hai, Chen, Jiun-Liang, Liu, Pei-Shan, Tsai, Ming-Ming, Wang, Su-Jane, Hsieh, Hsi-Lung
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7276071/
https://ncbi.nlm.nih.gov/pubmed/32505192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-01859-5
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