NADPH oxidase 2-derived reactive oxygen species signal contributes to bradykinin-induced matrix metalloproteinase-9 expression and cell migration in brain astrocytes

BACKGROUND: Matrix metalloproteinase-9 (MMP-9) plays a crucial role in pathological processes of brain inflammation, injury, and neurodegeneration. Moreover, bradykinin (BK) induces the expression of several inflammatory proteins in brain astrocytes. Recent studies have suggested that increased oxid...

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Bibliographic Details
Main Authors: Lin, Chih-Chung, Hsieh, Hsi-Lung, Shih, Ruey-Horng, Chi, Pei-Ling, Cheng, Shin-Ei, Chen, Jin-Chung, Yang, Chuen-Mao
Format: Artigo
Language:Inglês
Published: BioMed Central 2012
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3518199/
https://ncbi.nlm.nih.gov/pubmed/23176293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1478-811X-10-35
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