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Up-regulation of COX-2/PGE(2) by endothelin-1 via MAPK-dependent NF-κB pathway in mouse brain microvascular endothelial cells
BACKGROUND: Endothelin-1 (ET-1) is a proinflammatory mediator and elevated in the regions of several brain injury and inflammatory diseases. The deleterious effects of ET-1 on endothelial cells may aggravate brain inflammation mediated through the regulation of cyclooxygenase-2 (COX-2)/prostaglandin...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3560266/ https://ncbi.nlm.nih.gov/pubmed/23343326 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1478-811X-11-8 |
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