Up-regulation of COX-2/PGE(2) by endothelin-1 via MAPK-dependent NF-κB pathway in mouse brain microvascular endothelial cells

BACKGROUND: Endothelin-1 (ET-1) is a proinflammatory mediator and elevated in the regions of several brain injury and inflammatory diseases. The deleterious effects of ET-1 on endothelial cells may aggravate brain inflammation mediated through the regulation of cyclooxygenase-2 (COX-2)/prostaglandin...

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Autors principals: Lin, Chih-Chung, Hsieh, Hsi-Lung, Shih, Ruey-Horng, Chi, Pei-Ling, Cheng, Shin-Ei, Yang, Chuen-Mao
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2013
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3560266/
https://ncbi.nlm.nih.gov/pubmed/23343326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1478-811X-11-8
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