Role of TLR4/NADPH oxidase/ROS-activated p38 MAPK in VCAM-1 expression induced by lipopolysaccharide in human renal mesangial cells

<p>Abstract</p> <p>Background</p> <p>In bacteria-induced glomerulonephritis, Toll-like receptor 4 (TLR4) activation by lipopolysaccharide (LPS, a key component of the outer membranes of Gram-negative bacteria) can increase oxidative stress and the expression of vascular...

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Detalhes bibliográficos
Main Authors: Lee I-Ta, Shih Ruey-Horng, Lin Chih-Chung, Chen Jung-Tsan, Yang Chuen-Mao
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2012-11-01
Colecção:Cell Communication and Signaling
Assuntos:
Lipopolysaccharide
Vascular cell adhesion molecule-1
Toll-like receptors
Reactive oxygen species
NADPH oxidase
Acesso em linha:http://www.biosignaling.com/content/10/1/33
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