The Development of a Novel Nanobody Therapeutic for SARS-CoV-2

Combating the COVID-19 pandemic requires potent and low-cost therapeutics. We identified a novel series of single-domain antibodies (i.e., nanobody), Nanosota-1, from a camelid nanobody phage display library. Structural data showed that Nanosota-1 bound to the oft-hidden receptor-binding domain (RBD...

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Gepubliceerd in:bioRxiv
Hoofdauteurs: Ye, Gang, Gallant, Joseph P., Massey, Christopher, Shi, Ke, Tai, Wanbo, Zheng, Jian, Odle, Abby E., Vickers, Molly A., Shang, Jian, Wan, Yushun, Drelich, Aleksandra, Kempaiah, Kempaiah R., Tat, Vivian, Perlman, Stanley, Du, Lanying, Tseng, Chien-Te, Aihara, Hideki, LeBeau, Aaron M., Li, Fang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cold Spring Harbor Laboratory 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7685322/
https://ncbi.nlm.nih.gov/pubmed/33236012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.11.17.386532
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