The Development of a Novel Nanobody Therapeutic for SARS-CoV-2

Combating the COVID-19 pandemic requires potent and low-cost therapeutics. We identified a novel series of single-domain antibodies (i.e., nanobody), Nanosota-1, from a camelid nanobody phage display library. Structural data showed that Nanosota-1 bound to the oft-hidden receptor-binding domain (RBD...

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Vydáno v:bioRxiv
Hlavní autoři: Ye, Gang, Gallant, Joseph P., Massey, Christopher, Shi, Ke, Tai, Wanbo, Zheng, Jian, Odle, Abby E., Vickers, Molly A., Shang, Jian, Wan, Yushun, Drelich, Aleksandra, Kempaiah, Kempaiah R., Tat, Vivian, Perlman, Stanley, Du, Lanying, Tseng, Chien-Te, Aihara, Hideki, LeBeau, Aaron M., Li, Fang
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7685322/
https://ncbi.nlm.nih.gov/pubmed/33236012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.11.17.386532
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