The Development of a Novel Nanobody Therapeutic for SARS-CoV-2

Combating the COVID-19 pandemic requires potent and low-cost therapeutics. We identified a novel series of single-domain antibodies (i.e., nanobody), Nanosota-1, from a camelid nanobody phage display library. Structural data showed that Nanosota-1 bound to the oft-hidden receptor-binding domain (RBD...

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Publicado no:bioRxiv
Main Authors: Ye, Gang, Gallant, Joseph P., Massey, Christopher, Shi, Ke, Tai, Wanbo, Zheng, Jian, Odle, Abby E., Vickers, Molly A., Shang, Jian, Wan, Yushun, Drelich, Aleksandra, Kempaiah, Kempaiah R., Tat, Vivian, Perlman, Stanley, Du, Lanying, Tseng, Chien-Te, Aihara, Hideki, LeBeau, Aaron M., Li, Fang
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7685322/
https://ncbi.nlm.nih.gov/pubmed/33236012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.11.17.386532
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