The Development of a Novel Nanobody Therapeutic for SARS-CoV-2

Combating the COVID-19 pandemic requires potent and low-cost therapeutics. We identified a novel series of single-domain antibodies (i.e., nanobody), Nanosota-1, from a camelid nanobody phage display library. Structural data showed that Nanosota-1 bound to the oft-hidden receptor-binding domain (RBD...

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Bibliografske podrobnosti
izdano v:bioRxiv
Main Authors: Ye, Gang, Gallant, Joseph P., Massey, Christopher, Shi, Ke, Tai, Wanbo, Zheng, Jian, Odle, Abby E., Vickers, Molly A., Shang, Jian, Wan, Yushun, Drelich, Aleksandra, Kempaiah, Kempaiah R., Tat, Vivian, Perlman, Stanley, Du, Lanying, Tseng, Chien-Te, Aihara, Hideki, LeBeau, Aaron M., Li, Fang
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory 2020
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7685322/
https://ncbi.nlm.nih.gov/pubmed/33236012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.11.17.386532
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