An engineered receptor-binding domain improves the immunogenicity of multivalent SARS-CoV-2 vaccines

The SARS-coronavirus 2 (SARS-CoV-2) spike (S) protein mediates viral entry into cells expressing the angiotensin-converting enzyme 2 (ACE2). The S protein engages ACE2 through its receptor-binding domain (RBD), an independently folded 197-amino acid fragment of the 1273-amino acid S-protein protomer...

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Detalhes bibliográficos
Publicado no:bioRxiv
Main Authors: Quinlan, Brian D., He, Wenhui, Mou, Huihui, Zhang, Lizhou, Guo, Yan, Chang, Jing, Peng, Shoujiao, Ojha, Amrita, Tavora, Rubens, Parcells, Mark S., Luo, Guangxiang, Li, Wenhui, Zhong, Guocai, Choe, Hyeryun, Farzan, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7685318/
https://ncbi.nlm.nih.gov/pubmed/33236008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.11.18.388934
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