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An engineered receptor-binding domain improves the immunogenicity of multivalent SARS-CoV-2 vaccines

The SARS-coronavirus 2 (SARS-CoV-2) spike (S) protein mediates viral entry into cells expressing the angiotensin-converting enzyme 2 (ACE2). The S protein engages ACE2 through its receptor-binding domain (RBD), an independently folded 197-amino acid fragment of the 1273-amino acid S-protein protomer...

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Foilsithe in:bioRxiv
Main Authors: Quinlan, Brian D., He, Wenhui, Mou, Huihui, Zhang, Lizhou, Guo, Yan, Chang, Jing, Peng, Shoujiao, Ojha, Amrita, Tavora, Rubens, Parcells, Mark S., Luo, Guangxiang, Li, Wenhui, Zhong, Guocai, Choe, Hyeryun, Farzan, Michael
Formáid: Artigo
Teanga:Inglês
Foilsithe: Cold Spring Harbor Laboratory 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7685318/
https://ncbi.nlm.nih.gov/pubmed/33236008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.11.18.388934
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