SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity

SARS-CoV-2 variants with spike (S)-protein D614G mutations now predominate globally. We therefore compare the properties of the mutated S protein (S(G614)) with the original (S(D614)). We report here pseudoviruses carrying S(G614) enter ACE2-expressing cells more efficiently than those with S(D614)....

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Publicado no:Nat Commun
Main Authors: Zhang, Lizhou, Jackson, Cody B., Mou, Huihui, Ojha, Amrita, Peng, Haiyong, Quinlan, Brian D., Rangarajan, Erumbi S., Pan, Andi, Vanderheiden, Abigail, Suthar, Mehul S., Li, Wenhui, Izard, Tina, Rader, Christoph, Farzan, Michael, Choe, Hyeryun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7693302/
https://ncbi.nlm.nih.gov/pubmed/33243994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19808-4
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