Pyruvate kinase controls signal strength in the insulin secretory pathway

Pancreatic β-cells couple nutrient metabolism with appropriate insulin secretion. Here, we show that pyruvate kinase (PK), which converts ADP and phosphoenolpyruvate (PEP) into ATP and pyruvate, underlies β-cell sensing of both glycolytic and mitochondrial fuels. Plasma membrane-localized PK is suff...

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Bibliographic Details
Published in:	Cell Metab
Main Authors:	Lewandowski, Sophie L., Cardone, Rebecca L., Foster, Hannah R., Ho, Thuong, Potapenko, Evgeniy, Poudel, Chetan, VanDeusen, Halena R., Sdao, Sophia M., Alves, Tiago C., Zhao, Xiaojian, Capozzi, Megan E., de Souza, Arnaldo H., Jahan, Ishrat, Thomas, Craig J., Nunemaker, Craig S., Davis, Dawn Belt, Campbell, Jonathan E., Kibbey, Richard G., Merrins, Matthew J.
Format:	Artigo
Language:	Inglês
Published:	2020
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC7685238/ https://ncbi.nlm.nih.gov/pubmed/33147484 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2020.10.007
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Pyruvate kinase controls signal strength in the insulin secretory pathway

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