Metformin Inhibits Mouse Islet Insulin Secretion and Alters Intracellular Calcium in a Concentration-Dependent and Duration-Dependent Manner near the Circulating Range

Metformin is considered the first-line treatment for type 2 diabetes. While metformin primarily increases insulin sensitivity, evidence also suggests that metformin affects the activity of insulin-secreting pancreatic islets. This study was designed to systematically examine the direct effects of me...

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Опубликовано в: :J Diabetes Res
Главные авторы: Gelin, Lindor, Li, Jiewen, Corbin, Kathryn L., Jahan, Ishrat, Nunemaker, Craig S.
Формат: Artigo
Язык:Inglês
Опубликовано: Hindawi 2018
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5971297/
https://ncbi.nlm.nih.gov/pubmed/29862303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/9163052
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