Human cytomegalovirus-encoded viral cyclin-dependent kinase (v-CDK) UL97 phosphorylates and inactivates the retinoblastoma protein-related p107 and p130 proteins

The human cytomegalovirus (HCMV)-encoded viral cyclin-dependent kinase (v-CDK) UL97 phosphorylates the retinoblastoma (Rb) tumor suppressor. Here, we identify the other Rb family members p107 and p130 as novel targets of UL97. UL97 phosphorylates p107 and p130 thereby inhibiting their ability to rep...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Iwahori, Satoko, Umaña, Angie C., VanDeusen, Halena R., Kalejta, Robert F.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2017
Ämnen:
Cell Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399109/
https://ncbi.nlm.nih.gov/pubmed/28289097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.773150
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