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Human cytomegalovirus-encoded viral cyclin-dependent kinase (v-CDK) UL97 phosphorylates and inactivates the retinoblastoma protein-related p107 and p130 proteins

The human cytomegalovirus (HCMV)-encoded viral cyclin-dependent kinase (v-CDK) UL97 phosphorylates the retinoblastoma (Rb) tumor suppressor. Here, we identify the other Rb family members p107 and p130 as novel targets of UL97. UL97 phosphorylates p107 and p130 thereby inhibiting their ability to rep...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Iwahori, Satoko, Umaña, Angie C., VanDeusen, Halena R., Kalejta, Robert F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399109/
https://ncbi.nlm.nih.gov/pubmed/28289097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.773150
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