Autoantibodies against the prion protein in individuals with PRNP mutations

OBJECTIVE: To determine whether naturally occurring autoantibodies against the prion protein are present in individuals with genetic prion disease mutations and controls, and if so, whether they are protective against prion disease. METHODS: In this case–control study, we collected 124 blood samples...

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Veröffentlicht in:Neurology
Hauptverfasser: Frontzek, Karl, Carta, Manfredi, Losa, Marco, Epskamp, Mirka, Meisl, Georg, Anane, Alice, Brandel, Jean-Philippe, Camenisch, Ulrike, Castilla, Joaquín, Haïk, Stéphane, Knowles, Tuomas, Lindner, Ewald, Lutterotti, Andreas, Minikel, Eric Vallabh, Roiter, Ignazio, Safar, Jiri G., Sanchez-Valle, Raquel, Žáková, Dana, Hornemann, Simone, Aguzzi, Adriano
Format: Artigo
Sprache:Inglês
Veröffentlicht: Lippincott Williams & Wilkins 2020
Schlagworte:
Null Hypothesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7682844/
https://ncbi.nlm.nih.gov/pubmed/32098855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000009183
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