Endogenous glucocorticoid signaling regulates effector differentiation and development of dysfunction in CD8(+) T cells in the tumor microenvironment

Identifying signals in the tumor microenvironment (TME) that shape CD8(+) T cell phenotype can inform novel therapeutic approaches for cancer. Here, we identified a gradient of increasing glucocorticoid receptor (GR) expression and signaling from naive to dysfunctional CD8(+) tumor-infiltrating lymp...

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Publicado en:Immunity
Main Authors: Acharya, Nandini, Madi, Asaf, Zhang, Huiyuan, Klapholz, Max, Escobar, Giulia, Dulberg, Shai, Christian, Elena, Ferreira, Michelle, Dixon, Karen O., Fell, Geoffrey, Tooley, Katherine, Mangani, Davide, Xia, Junrong, Singer, Meromit, Bosenberg, Marcus, Neuberg, Donna, Rozenblatt-Rosen, Orit, Regev, Aviv, Kuchroo, Vijay K., Anderson, Ana C.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7682805/
https://ncbi.nlm.nih.gov/pubmed/32937153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2020.08.005
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