Checkpoint blockade immunotherapy induces dynamic changes in PD-1(−)CD8(+) tumor-infiltrating T cells

An improved understanding of the anti-tumor CD8(+) T cell response after checkpoint blockade would enable more informed and effective therapeutic strategies. Here we examined the dynamics of the effector response of CD8(+) tumor-infiltrating lymphocytes (TILs) after checkpoint blockade therapy. Bulk...

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Publicado en:Immunity
Autores principales: Kurtulus, Sema, Madi, Asaf, Escobar, Giulia, Klapholz, Max, Nyman, Jackson, Pawlak, Mathias, Dionne, Danielle, Xia, Junrong, Rozenblatt-Rosen, Orit, Kuchroo, Vijay K., Regev, Aviv, Anderson, Ana C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6336113/
https://ncbi.nlm.nih.gov/pubmed/30635236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.11.014
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