Induction and transcriptional regulation of the co-inhibitory gene module in T cells

Expression of co-inhibitory receptors, such as CTLA-4 and PD-1, on effector T cells is a key mechanism for ensuring immune homeostasis. Dysregulated co-inhibitory receptor expression on CD4(+) T cells promotes autoimmunity while sustained overexpression on CD8(+) T cells promotes T cell dysfunction...

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Pubblicato in:Nature
Autori principali: Chihara, Norio, Madi, Asaf, Kondo, Takaaki, Zhang, Huiyuan, Acharya, Nandini, Singer, Meromit, Nyman, Jackson, Marjanovic, Nemanja D., Kowalczyk, Monika S., Wang, Chao, Kurtulus, Sema, Law, Travis, Etminan, Yasaman, Nevin, James, Buckley, Christopher D., Burkett, Patrick R., Buenrostro, Jason D., Rozenblatt-Rosen, Orit, Anderson, Ana C., Regev, Aviv, Kuchroo, Vijay K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6130914/
https://ncbi.nlm.nih.gov/pubmed/29899446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0206-z
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