PAR1 (Protease-Activated Receptor 1) Pepducin Therapy Targeting Myocardial Necrosis in Coronary Artery Disease and Acute Coronary Syndrome Patients Undergoing Cardiac Catheterization: A Randomized, Placebo-Controlled, Phase 2 Study

OBJECTIVE: Arterial thrombosis leading to ischemic injury worsens the prognosis of many patients with cardiovascular disease. PZ-128 is a first-in-class pepducin that reversibly inhibits PAR1 (protease-activated receptor 1) on platelets and other vascular cells by targeting the intracellular surface...

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Detalles Bibliográficos
Publicado en:Arterioscler Thromb Vasc Biol
Autores principales: Kuliopulos, Athan, Gurbel, Paul A., Rade, Jeffrey J., Kimmelstiel, Carey D., Turner, Susan E., Bliden, Kevin P., Fletcher, Elizabeth K., Cox, Daniel H., Covic, Lidija
Formato: Artigo
Lenguaje:Inglês
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Clinical and Population Studies
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7682800/
https://ncbi.nlm.nih.gov/pubmed/33028101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.120.315168
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