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Deficiency of MMP1a Collagenase Suppresses Development of Atherosclerosis in Mice: Translational Implications for Human Coronary Artery Disease

OBJECTIVE: Destruction of arterial collagen allows monocyte and macrophage infiltration leading to atherosclerotic plaque formation, but it is not clear what role the MMP1 collagenase plays in this process in vivo. To define the specific contribution of MMP1 to atherosclerotic plaque burden and path...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Arterioscler Thromb Vasc Biol
Prif Awduron: Fletcher, Elizabeth K., Wang, Yanling, Flynn, Laura K., Turner, Susan E., Rade, Jeffrey J., Kimmelstiel, Carey D., Gurbel, Paul A., Bliden, Kevin P., Covic, Lidija, Kuliopulos, Athan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2021
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8062306/
https://ncbi.nlm.nih.gov/pubmed/33761760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.120.315837
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