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Deficiency of MMP1a Collagenase Suppresses Development of Atherosclerosis in Mice: Translational Implications for Human Coronary Artery Disease

OBJECTIVE: Destruction of arterial collagen allows monocyte and macrophage infiltration leading to atherosclerotic plaque formation, but it is not clear what role the MMP1 collagenase plays in this process in vivo. To define the specific contribution of MMP1 to atherosclerotic plaque burden and path...

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Detalhes bibliográficos
Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Fletcher, Elizabeth K., Wang, Yanling, Flynn, Laura K., Turner, Susan E., Rade, Jeffrey J., Kimmelstiel, Carey D., Gurbel, Paul A., Bliden, Kevin P., Covic, Lidija, Kuliopulos, Athan
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8062306/
https://ncbi.nlm.nih.gov/pubmed/33761760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.120.315837
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