The structural basis for an on–off switch controlling Gβγ-mediated inhibition of TRPM3 channels

TRPM3 channels play important roles in the detection of noxious heat and in inflammatory thermal hyperalgesia. The activity of these ion channels in somatosensory neurons is tightly regulated by µ-opioid receptors through the signaling of Gβγ proteins, thereby reducing TRPM3-mediated pain. We show h...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Behrendt, Marc, Gruss, Fabian, Enzeroth, Raissa, Dembla, Sandeep, Zhao, Siyuan, Crassous, Pierre-Antoine, Mohr, Florian, Nys, Mieke, Louros, Nikolaos, Gallardo, Rodrigo, Zorzini, Valentina, Wagner, Doris, Economou, Anastassios, Rousseau, Frederic, Schymkowitz, Joost, Philipp, Stephan E., Rohacs, Tibor, Ulens, Chris, Oberwinkler, Johannes
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7682392/
https://ncbi.nlm.nih.gov/pubmed/33122432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2001177117
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