The structural basis for an on–off switch controlling Gβγ-mediated inhibition of TRPM3 channels

TRPM3 channels play important roles in the detection of noxious heat and in inflammatory thermal hyperalgesia. The activity of these ion channels in somatosensory neurons is tightly regulated by µ-opioid receptors through the signaling of Gβγ proteins, thereby reducing TRPM3-mediated pain. We show h...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Behrendt, Marc, Gruss, Fabian, Enzeroth, Raissa, Dembla, Sandeep, Zhao, Siyuan, Crassous, Pierre-Antoine, Mohr, Florian, Nys, Mieke, Louros, Nikolaos, Gallardo, Rodrigo, Zorzini, Valentina, Wagner, Doris, Economou, Anastassios, Rousseau, Frederic, Schymkowitz, Joost, Philipp, Stephan E., Rohacs, Tibor, Ulens, Chris, Oberwinkler, Johannes
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7682392/
https://ncbi.nlm.nih.gov/pubmed/33122432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2001177117
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