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Disease-associated mutations in the human TRPM3 render the channel overactive via two distinct mechanisms
Transient Receptor Potential Melastatin 3 (TRPM3) is a Ca(2+) permeable non-selective cation channel activated by heat and chemical agonists such as pregnenolone sulfate and CIM0216. TRPM3 mutations in humans were recently reported to be associated with intellectual disability and epilepsy; the func...
Shranjeno v:
| izdano v: | eLife |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
eLife Sciences Publications, Ltd
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7255801/ https://ncbi.nlm.nih.gov/pubmed/32343227 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.55634 |
| Oznake: |
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