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The G‐protein‐biased agents PZM21 and TRV130 are partial agonists of μ‐opioid receptor‐mediated signalling to ion channels
BACKGROUND AND PURPOSE: Opioids remain the most efficient medications against severe pain; they act on receptors that couple to heterotrimeric G‐proteins in the G(αi/o) family. Opioids exert many of their acute effects through modulating ion channels via G(βγ) subunits. Many of their side effects ar...
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| Veröffentlicht in: | Br J Pharmacol |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley and Sons Inc.
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6692666/ https://ncbi.nlm.nih.gov/pubmed/31074038 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14702 |
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