Antinociceptive, reinforcing, and pruritic effects of the G-protein signalling-biased mu opioid receptor agonist PZM21 in non-human primates

BACKGROUND: A novel G-protein signalling-biased mu opioid peptide (MOP) receptor agonist, PZM21, was recently developed with a distinct chemical structure. It is a potent G(i/o) activator with minimal β-arrestin-2 recruitment. Despite intriguing activity in rodent models, PZM21 function in non-human...

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Bibliographische Detailangaben
Veröffentlicht in:Br J Anaesth
Hauptverfasser: Ding, Huiping, Kiguchi, Norikazu, Perrey, David A., Nguyen, Thuy, Czoty, Paul W., Hsu, Fang-Chi, Zhang, Yanan, Ko, Mei-Chuan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020
Schlagworte:
Pain
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7565907/
https://ncbi.nlm.nih.gov/pubmed/32819621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bja.2020.06.057
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