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TDP-43 proteinopathy impairs mRNP granule mediated postsynaptic translation and mRNA metabolism
Background: Local protein synthesis and mRNA metabolism mediated by mRNP granules in the dendrites and the postsynaptic compartment is essential for synaptic remodeling and plasticity in neuronal cells. Dysregulation of these processes caused by TDP-43 proteinopathy leads to neurodegenerative diseas...
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| Publié dans: | Theranostics |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Ivyspring International Publisher
2021
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7681104/ https://ncbi.nlm.nih.gov/pubmed/33391478 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.51004 |
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