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HDAC1 dysregulation induces aberrant cell cycle and DNA damage in progress of TDP‐43 proteinopathies

Abstract TAR DNA‐binding protein 43 (TDP‐43) has been implicated in frontotemporal lobar degeneration with ubiquitin‐positive inclusions (FTLD‐TDP) and amyotrophic lateral sclerosis. Histone deacetylase 1 (HDAC1) is involved in DNA repair and neuroprotection in numerous neurodegenerative diseases. H...

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Huvudupphov: Cheng‐Chun Wu, Lee‐Way Jin, I‐Fang Wang, Wei‐Yen Wei, Pei‐Chuan Ho, Yu‐Chih Liu, Kuen‐Jer Tsai
Materialtyp: Artigo
Språk:Inglês
Utgiven: Springer Nature 2020-05-01
Serie:EMBO Molecular Medicine
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Länkar:https://doi.org/10.15252/emmm.201910622
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