O‐GlcNAcylation of TDP‐43 suppresses proteinopathies and promotes TDP‐43’s mRNA splicing activity

Pathological TDP‐43 aggregation is characteristic of several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD‐TDP); however, how TDP‐43 aggregation and function are regulated remain poorly understood. Here, we show that O‐GlcNAc tr...

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Publicat a:EMBO Rep
Autors principals: Zhao, Meng‐Jie, Yao, Xiao, Wei, Ping, Zhao, Chen, Cheng, Meng, Zhang, Dong, Xue, Wen, He, Wen‐Tian, Xue, Weili, Zuo, Xinxin, Jiang, Lei‐Lei, Luo, Zhiyuan, Song, Jiaqi, Shu, Wen‐Jie, Yuan, Han‐Ye, Liang, Yi, Sun, Hui, Zhou, Yan, Zhou, Yu, Zheng, Ling, Hu, Hong‐Yu, Wang, Jiwu, Du, Hai‐Ning
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2021
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8183420/
https://ncbi.nlm.nih.gov/pubmed/33855783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.202051649
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