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Simulations of octapeptin–outer membrane interactions reveal conformational flexibility is linked to antimicrobial potency
The octapeptins are lipopeptide antibiotics that are structurally similar to polymyxins yet retain activity against polymyxin-resistant Gram-negative pathogens, suggesting they might be used to treat recalcitrant infections. However, the basis of their unique activity is unclear because of the diffi...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7681018/ https://ncbi.nlm.nih.gov/pubmed/32913118 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014856 |
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