Simulations of octapeptin–outer membrane interactions reveal conformational flexibility is linked to antimicrobial potency

The octapeptins are lipopeptide antibiotics that are structurally similar to polymyxins yet retain activity against polymyxin-resistant Gram-negative pathogens, suggesting they might be used to treat recalcitrant infections. However, the basis of their unique activity is unclear because of the diffi...

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Vydáno v:J Biol Chem
Hlavní autoři: Jiang, Xukai, Yang, Kai, Yuan, Bing, Gong, Bin, Wan, Lin, Patil, Nitin A., Swarbrick, James D., Roberts, Kade D., Schreiber, Falk, Wang, Lushan, Velkov, Tony, Li, Jian
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2020
Témata:
Computational Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7681018/
https://ncbi.nlm.nih.gov/pubmed/32913118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014856
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