Pyrexia and acidosis act independently of neutrophil elastase reactive center loop cleavage to effect cortisol release from corticosteroid‐binding globulin

Corticosteroid‐binding globulin (CBG) transports cortisol and other steroids. High‐affinity CBG (haCBG) undergoes proteolysis of the reactive center loop (RCL) by neutrophil elastase (NE) altering conformation to low‐affinity CBG (laCBG). Elevated temperature reduces CBG:cortisol binding affinity. S...

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Udgivet i:Protein Sci
Main Authors: Meyer, Emily J., Torpy, David J., Chernykh, Anastasia, Thaysen‐Andersen, Morten, Nenke, Marni A., Lewis, John G., Rajapaksha, Harinda, Rankin, Wayne, Polyak, Steven W.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley & Sons, Inc. 2020
Fag:
Full‐Length Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7679970/
https://ncbi.nlm.nih.gov/pubmed/33085168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3982
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