Neutrophil elastase-cleaved corticosteroid-binding globulin is absent in human plasma

Corticosteroid-binding globulin (CBG) transports glucocorticoids in blood and is a serine protease inhibitor family member. Human CBG has a reactive center loop (RCL) which, when cleaved by neutrophil elastase (NE), disrupts its steroid-binding activity. Measurements of CBG levels are typically base...

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Detalhes bibliográficos
Publicado no:J Endocrinol
Main Authors: Hill, Lesley A, Vassiliadi, Dimitra A, Dimopoulou, Ioanna, Anderson, Anna J, Boyle, Luke D, Kilgour, Alixe H M, Stimson, Roland H, Machado, Yoan, Overall, Christopher M, Walker, Brian R, Lewis, John G, Hammond, Geoffrey L
Formato: Artigo
Idioma:Inglês
Publicado em: Bioscientifica Ltd 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6347282/
https://ncbi.nlm.nih.gov/pubmed/30452386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JOE-18-0479
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