Pseudomonas Aeruginosa Elastase Disrupts the Cortisol-Binding Activity of Corticosteroid-Binding Globulin

The serine protease inhibitor (SERPIN) family member corticosteroid-binding globulin (CBG) is the main carrier of glucocorticoids in plasma. Human CBG mediates the targeted release of cortisol at sites of inflammation through cleavage of its reactive center loop (RCL) by neutrophil elastase. The RCL...

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Detalhes bibliográficos
Main Authors: Simard, Marc, Hill, Lesley A., Underhill, Caroline M., Keller, Bernd O., Villanueva, Ivan, Hancock, Robert E. W., Hammond, Geoffrey L.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2014
Assuntos:
Glucocorticoids-CRH-ACTH-Adrenal
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4098004/
https://ncbi.nlm.nih.gov/pubmed/24848868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1055
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