Pseudomonas Aeruginosa Elastase Disrupts the Cortisol-Binding Activity of Corticosteroid-Binding Globulin

The serine protease inhibitor (SERPIN) family member corticosteroid-binding globulin (CBG) is the main carrier of glucocorticoids in plasma. Human CBG mediates the targeted release of cortisol at sites of inflammation through cleavage of its reactive center loop (RCL) by neutrophil elastase. The RCL...

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Détails bibliographiques
Auteurs principaux: Simard, Marc, Hill, Lesley A., Underhill, Caroline M., Keller, Bernd O., Villanueva, Ivan, Hancock, Robert E. W., Hammond, Geoffrey L.
Format: Artigo
Langue:Inglês
Publié: Endocrine Society 2014
Sujets:
Glucocorticoids-CRH-ACTH-Adrenal
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4098004/
https://ncbi.nlm.nih.gov/pubmed/24848868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1055
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