Pyrexia and acidosis act independently of neutrophil elastase reactive center loop cleavage to effect cortisol release from corticosteroid‐binding globulin

Corticosteroid‐binding globulin (CBG) transports cortisol and other steroids. High‐affinity CBG (haCBG) undergoes proteolysis of the reactive center loop (RCL) by neutrophil elastase (NE) altering conformation to low‐affinity CBG (laCBG). Elevated temperature reduces CBG:cortisol binding affinity. S...

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Publicado en:Protein Sci
Main Authors: Meyer, Emily J., Torpy, David J., Chernykh, Anastasia, Thaysen‐Andersen, Morten, Nenke, Marni A., Lewis, John G., Rajapaksha, Harinda, Rankin, Wayne, Polyak, Steven W.
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley & Sons, Inc. 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7679970/
https://ncbi.nlm.nih.gov/pubmed/33085168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3982
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