Pyrexia and acidosis act independently of neutrophil elastase reactive center loop cleavage to effect cortisol release from corticosteroid‐binding globulin

Corticosteroid‐binding globulin (CBG) transports cortisol and other steroids. High‐affinity CBG (haCBG) undergoes proteolysis of the reactive center loop (RCL) by neutrophil elastase (NE) altering conformation to low‐affinity CBG (laCBG). Elevated temperature reduces CBG:cortisol binding affinity. S...

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Bibliografski detalji
Izdano u:Protein Sci
Glavni autori: Meyer, Emily J., Torpy, David J., Chernykh, Anastasia, Thaysen‐Andersen, Morten, Nenke, Marni A., Lewis, John G., Rajapaksha, Harinda, Rankin, Wayne, Polyak, Steven W.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley & Sons, Inc. 2020
Teme:
Full‐Length Papers
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7679970/
https://ncbi.nlm.nih.gov/pubmed/33085168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3982
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