Pyrexia and acidosis act independently of neutrophil elastase reactive center loop cleavage to effect cortisol release from corticosteroid‐binding globulin

Corticosteroid‐binding globulin (CBG) transports cortisol and other steroids. High‐affinity CBG (haCBG) undergoes proteolysis of the reactive center loop (RCL) by neutrophil elastase (NE) altering conformation to low‐affinity CBG (laCBG). Elevated temperature reduces CBG:cortisol binding affinity. S...

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Detalhes bibliográficos
Publicado no:Protein Sci
Main Authors: Meyer, Emily J., Torpy, David J., Chernykh, Anastasia, Thaysen‐Andersen, Morten, Nenke, Marni A., Lewis, John G., Rajapaksha, Harinda, Rankin, Wayne, Polyak, Steven W.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Inc. 2020
Assuntos:
Full‐Length Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7679970/
https://ncbi.nlm.nih.gov/pubmed/33085168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3982
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