Discovery of regulatory noncoding variants in individual cancer genomes by using cis-X

We developed cis-X, a computational method for discovery of regulatory noncoding variants in cancer by integrating whole genome and transcriptome sequencing data from a single cancer sample. cis-X first finds aberrantly cis-activated genes that exhibit allele-specific expression accompanied by an el...

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Publicado no:Nat Genet
Main Authors: Liu, Yu, Li, Chunliang, Shen, Shuhong, Chen, Xiaolong, Szlachta, Karol, Edmonson, Michael N., Shao, Ying, Ma, Xiaotu, Hyle, Judith, Wright, Shaela, Ju, Bensheng, Rusch, Michael C., Liu, Yanling, Li, Benshang, Macias, Michael, Tian, Liqing, Easton, John, Qian, Maoxiang, Yang, Jun J., Hu, Shaoyan, Look, A. Thomas, Zhang, Jinghui
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7679232/
https://ncbi.nlm.nih.gov/pubmed/32632335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-0659-5
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