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A cis-element within the ARF locus mediates repression of p16(INK4A) expression via long-range chromatin interactions

Loss of function of CDKN2A/B, also known as INK4/ARF [encoding p16(INK4A), p15(INK4B), and p14(ARF) (mouse p19(Arf))], confers susceptibility to cancers, whereas its up-regulation during organismal aging provokes cellular senescence and tissue degenerative disorders. To better understand the transcr...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Zhang, Yang, Hyle, Judith, Wright, Shaela, Shao, Ying, Zhao, Xujie, Zhang, Hui, Li, Chunliang
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6936709/
https://ncbi.nlm.nih.gov/pubmed/31818950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1909720116
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