A carregar...
Development of dual and selective degraders of cyclin-dependent kinases 4 and 6
Cyclin-dependent kinases 4 and 6 (CDK4/6) are key regulators of the cell cycle, and CDK4/6 inhibitors are FDA-approved for treating patients with metastatic breast cancer. However, due to conservation of their ATP-binding sites, development of selective agents has remained elusive. Here, we report i...
Na minha lista:
| Publicado no: | Angew Chem Int Ed Engl |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7678623/ https://ncbi.nlm.nih.gov/pubmed/30802347 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201901336 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|