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Development of dual and selective degraders of cyclin-dependent kinases 4 and 6
Cyclin-dependent kinases 4 and 6 (CDK4/6) are key regulators of the cell cycle, and CDK4/6 inhibitors are FDA-approved for treating patients with metastatic breast cancer. However, due to conservation of their ATP-binding sites, development of selective agents has remained elusive. Here, we report i...
Kaydedildi:
| Yayımlandı: | Angew Chem Int Ed Engl |
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| Asıl Yazarlar: | , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2019
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7678623/ https://ncbi.nlm.nih.gov/pubmed/30802347 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201901336 |
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