Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma

Malignant glioma, the most common primary brain tumor, is generally incurable. Although phosphatidylinositol-3-kinase (PI3K) signaling features prominently in glioma, inhibitors generally block proliferation rather than induce apoptosis. Starting with an inhibitor of both lipid and protein kinases t...

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Detalhes bibliográficos
Main Authors: Cheng, Christine K., Gustafson, W. Clay, Charron, Elizabeth, Houseman, Benjamin T., Zunder, Eli, Goga, Andrei, Gray, Nathanael S., Pollok, Brian, Oakes, Scott A., James, C. David, Shokat, Kevan M., Weiss, William A., Fan, Qi-Wen
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411950/
https://ncbi.nlm.nih.gov/pubmed/22802621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1202492109
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