Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma

Malignant glioma, the most common primary brain tumor, is generally incurable. Although phosphatidylinositol-3-kinase (PI3K) signaling features prominently in glioma, inhibitors generally block proliferation rather than induce apoptosis. Starting with an inhibitor of both lipid and protein kinases t...

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Main Authors: Cheng, Christine K., Gustafson, W. Clay, Charron, Elizabeth, Houseman, Benjamin T., Zunder, Eli, Goga, Andrei, Gray, Nathanael S., Pollok, Brian, Oakes, Scott A., James, C. David, Shokat, Kevan M., Weiss, William A., Fan, Qi-Wen
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2012
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411950/
https://ncbi.nlm.nih.gov/pubmed/22802621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1202492109
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