Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma

Malignant glioma, the most common primary brain tumor, is generally incurable. Although phosphatidylinositol-3-kinase (PI3K) signaling features prominently in glioma, inhibitors generally block proliferation rather than induce apoptosis. Starting with an inhibitor of both lipid and protein kinases t...

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Autors principals: Cheng, Christine K., Gustafson, W. Clay, Charron, Elizabeth, Houseman, Benjamin T., Zunder, Eli, Goga, Andrei, Gray, Nathanael S., Pollok, Brian, Oakes, Scott A., James, C. David, Shokat, Kevan M., Weiss, William A., Fan, Qi-Wen
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411950/
https://ncbi.nlm.nih.gov/pubmed/22802621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1202492109
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