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Complexities of a protonatable substrate in measurements of Hoechst 33342 transport by multidrug transporter LmrP

Multidrug transporters can confer drug resistance on cells by extruding structurally unrelated compounds from the cellular interior. In transport assays, Hoechst 33342 (referred to as Hoechst) is a commonly used substrate, the fluorescence of which changes in the transport process. With three basic...

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Vydáno v:Sci Rep
Hlavní autoři: Swain, Brendan M., Guo, Dawei, Singh, Himansha, Rawlins, Philip B., McAlister, Mark, van Veen, Hendrik W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7674423/
https://ncbi.nlm.nih.gov/pubmed/33208856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-76943-0
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