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Complexities of a protonatable substrate in measurements of Hoechst 33342 transport by multidrug transporter LmrP

Multidrug transporters can confer drug resistance on cells by extruding structurally unrelated compounds from the cellular interior. In transport assays, Hoechst 33342 (referred to as Hoechst) is a commonly used substrate, the fluorescence of which changes in the transport process. With three basic...

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Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Swain, Brendan M., Guo, Dawei, Singh, Himansha, Rawlins, Philip B., McAlister, Mark, van Veen, Hendrik W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7674423/
https://ncbi.nlm.nih.gov/pubmed/33208856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-76943-0
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