Structural Insights into Inhibition of the Acinetobacter-Derived Cephalosporinase ADC-7 by Ceftazidime and Its Boronic Acid Transition State Analog

Extended-spectrum class C β-lactamases have evolved to rapidly inactivate expanded-spectrum cephalosporins, a class of antibiotics designed to be resistant to hydrolysis by β-lactamase enzymes. To better understand the mechanism by which Acinetobacter-derived cephalosporinase-7 (ADC-7), a chromosoma...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Curtis, Brandy N., Smolen, Kali A., Barlow, Sara J., Caselli, Emilia, Prati, Fabio, Taracila, Magdalena A., Bonomo, Robert A., Wallar, Bradley J., Powers, Rachel A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7674067/
https://ncbi.nlm.nih.gov/pubmed/32988830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01183-20
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