Inhibition of Acinetobacter-Derived Cephalosporinase: Exploring the Carboxylate Recognition Site Using Novel β-Lactamase Inhibitors

Boronic acids are attracting a lot of attention as β-lactamase inhibitors, and in particular, compound S02030 (K(i) = 44 nM) proved to be a good lead compound against ADC-7 (Acinetobacter-derived cephalosporinase), one of the most significant resistance determinants in A. baumannii. The atomic struc...

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Vydáno v:ACS Infect Dis
Hlavní autoři: Caselli, Emilia, Romagnoli, Chiara, Powers, Rachel A., Taracila, Magdalena A., Bouza, Alexandra A., Swanson, Hollister C., Smolen, Kali A., Fini, Francesco, Wallar, Bradley J., Bonomo, Robert A., Prati, Fabio
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5987196/
https://ncbi.nlm.nih.gov/pubmed/29144725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.7b00153
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