Determinants of seeding and spreading of α-synuclein pathology in the brain

In Parkinson’s disease (PD), fibrillar forms of α-synuclein are hypothesized to propagate through synaptically coupled networks, causing Lewy pathology (LP) and neurodegeneration. To more rigorously characterize the determinants of spreading, preformed α-synuclein fibrils were injected into the mous...

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Udgivet i:Sci Adv
Main Authors: Henrich, Martin T., Geibl, Fanni F., Lakshminarasimhan, Harini, Stegmann, Anna, Giasson, Benoit I., Mao, Xiaobo, Dawson, Valina L., Dawson, Ted M., Oertel, Wolfgang H., Surmeier, D. James
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2020
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7673735/
https://ncbi.nlm.nih.gov/pubmed/33177086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abc2487
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