A53T-α-synuclein overexpression in murine locus coeruleus induces Parkinson’s disease-like pathology in neurons and glia

Degeneration of noradrenergic locus coeruleus neurons occurs during the prodromal phase of Parkinson’s disease and contributes to a variety of non-motor symptoms, e.g. depression, anxiety and REM sleep behavior disorder. This study was designed to establish the first locus coeruleus α-synucleinopath...

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Bibliographic Details
Published in:Acta Neuropathol Commun
Main Authors: Henrich, Martin Timo, Geibl, Fanni Fruzsina, Lee, Bolam, Chiu, Wei-Hua, Koprich, James Benjamin, Brotchie, Jonathan Michael, Timmermann, Lars, Decher, Niels, Matschke, Lina Anita, Oertel, Wolfgang Hermann
Format: Artigo
Language:Inglês
Published: BioMed Central 2018
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5946574/
https://ncbi.nlm.nih.gov/pubmed/29747690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-018-0541-1
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